Table 2.
Up-regulated lncRNAs in schizophrenia (Empty cells show that this information has not been provided in the main articles).
| LncRNAs | Samples | Source | Targets/Regulators | Signaling pathways | Functional roles | References |
|---|---|---|---|---|---|---|
| NONHSAT089447 | 40 SCZ patients and 40 healthy controls | PBMC | DRD3 and DRD5 | Dopamine pathway | Dopamine receptors DRD3 and DRD5, and their downstream signals were activated by NONHSAT089447 expression. | (25) |
| NONHSAT041499 | 106 SCZ patients and 48 healthy controls | PBMC | Neuron apoptosis, learning, memory, behavior, sensory perception of sound, synapse organization and activity, layer formation in the cerebral cortex, stress-activated protein kinase signaling pathway and Ras protein signal transduction | ΔCT value of NONHSAT041499 was significantly higher in patients after the treatment, representing the substantial down-regulation of this lncRNA expression by the treatment. The symptomatology score and total score were meaningfully reduced following treatment. | (17) | |
| NONHSAT098126 | These transcripts have been suggested as markers for the diagnosis and prognostic evaluations. | |||||
| NONHSAT021545 | ||||||
| NONHSAT104778 | ||||||
| MEG3 | 86 SCZ patients and 44 healthy controls | PBMC | Chronic inflammatory pathway | Expression of MEG3 is lower in patients received risperidone treatment compared to those not receiving this drug. | (22) | |
| THRIL | 50 SCZ patients and 50 healthy controls | Blood | THRIL showed higher expression levels only in male subjects. This sex-based correlations imply the influence of sex hormones on its expressions. | (24) | ||
| HOXA-AS2 Linc-ROR MEG3 SPRY4-IT1 UCA1 MALAT1 |
60 SCZ patients and 60 healthy controls | Blood | HOXA-AS2, Linc-ROR, MEG3, UCA1, and SPRY4-IT1 are significantly up-regulated in total patients compared with total controls, but when evaluating in sex-specific manner, they only show significantly differences among female patients. There is also significant correlation between expression of HOXA-AS2, MALAT1, and UCA1 and age of participants in both patients and controls. |
(26) | ||
| TCONS_00019174 ENST00000566208 NONHSAG045500 ENST00000517573 NONHSAT034045 NONHSAT142707 |
45 SCZ patients and 40 healthy controls | PBMC | The mentioned lncRNAs show lower levels in major depressive disorder in comparison with control group. But these lncRNAs show opposite trend in schizophrenia. | (28) | ||
| AC006129.1 | 157 SCZ patients and 134 healthy controls | Blood | SOCS3 and CASP1 | Inflammatory response | AC006129.1 binds to the promoter of the transcriptional repressor Capicua, enhancing the interplay of DNA methyltransferases with the its promoter, thus amending CIC-induced SOCS3 and CASP1 suppression. | (27) |