Fig. 2.

SARS-CoV-2 N protein variations in disordered regions containing 14-3-3 binding sites and co-evolution analysis. A, B) Heat maps showing amino acid mutations in two selected disordered regions of the SARS-CoV-2 N protein containing putative 14-3-3 binding sites. C) Percentages of amino acid variations in sites surrounding S197, the most important in 14-3-3 binding. D, E) Co-evolution network of N protein amino acids calculated by OMES (D), and DCA method (E). Lines thickness are proportional to the co-evolution score (minimum = 0, maximum = 1).