TABLE 1.

Pharmacokinetic parameters of acetaminophen in rat plasma after exposure to simulated high altitude hypoxia.

Parameters	Normoxia	Acute hypoxia	Chronic hypoxia
Ke, 1/h	0.34 ± 0.02	0.29 ± 0.01 a	0.24 ± 0.01 a , b
t1/2, h	2.03 ± 0.11	2.47 ± 0.08 a	2.86 ± 0.14 a , b
MRT(0–12), h	2.80 ± 0.31	3.35 ± 0.08 a	3.49 ± 0.25 a
CL/F, L/kg/h	1.60 ± 0.23	0.83 ± 0.11 a	0.69 ± 0.14 a
Vd/F, L/kg	4.68 ± 0.64	2.92 ± 0.41 a	2.87 ± 0.64 a
AUC(0–12), h·μg/ml	64.22 ± 9.63	125.52 ± 17.75 a	149.86 ± 29.95 a
AUC(0-∞), h·μg/ml	67.63 ± 10.20	129.75 ± 18.36 a	158.22 ± 31.89 a
AUMC(0–12), h2·μg/ml	180.39 ± 35.15	419.48 ± 69.26 a	525.59 ± 127.72 a
AUMC(0-∞), h2·μg/ml	230.28 ± 40.37	534.41 ± 105.60 a	708.72 ± 184.89 a
Tmax, h	1.02 ± 0.07	1.09 ± 0.09	1.08 ± 0.12
Cmax, μg/ml	17.97 ± 2.73	31.77 ± 3.76 a	34.80 ± 5.24 a

Data are expressed as the mean ± SD values (n = 8).

^a p < 0.01 compared to the normoxia group;

^b p < 0.01 compared to the acute hypoxia group. ke, elimination rate constant; t_1/2, half-life; CL/F, total plasma clearance; Vd/F, apparent volume of distribution; Cmax, the maximum plasma concentration; AUC, area under the concentration time curve; AUMC, AUC of the first moment; MRT, mean residence time.