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Anti-migraine mechanism of action of magnesium: Migraine is due to mainly three reasons such as platelet activation, CGRP release and cortical spreading depression. Magnesium exhibiting its Antimigraine action through inhibiting platelet aggregation, serotonin release, inhibiting CGRP mediated vasodilation, and inhibiting CSD. 5 HT-serotonin, CGRP calcitonin gene related peptide, NMDA N methyl D aspartic acid receptor, CSD cortical spreading depression
