Fig. 6.

Showing factors leading to hearing loss and beneficial role of magnesium in it: hearing loss is mainly due to three main reasons; noise induced, drug induced and sudden sensioneural hearing loss. The ionic change associated with hearing loss is corrected by magnesium due to its calcium antagonist action and ischemic related problem are corrected by its vasodilatory property. Excitotoxicity in association with hearing loss is corrected by its non-competitive NMDA antagonist action. Additionally antioxidant action of magnesium is beneficial in oxidative stress and related apoptosis