Table 3.
List of magnesium transporters in different organs and diseasesassociated with its abnormalities
| Transporter | Expression | Associated diseases |
|---|---|---|
| Members of the Cyclin M (CNNM) | ||
| CNNM1 | Brain | Urofacial Syndrome 1 and Jalili Syndrome |
| CNNM2 | Kidney | Hypomagnesemia with seizure and mental retardation |
| CNNM3 | Ubiquitous expression | Pneumonic Tularemia and Jalili Syndrome |
| CNNM4 | Intestine | Jallili syndrome |
| Transient receptor potential melastatin cation channels | ||
| TRPM6 | Kidney, intestine | Hypomagnesemia with secondary hypocalcemia |
| TRPM7 | Ubiquitous | Cardiac fibrosis, atrial fibrillation, anoxic brain injury |
| Solute carrier family 41 member | ||
| SLC41A1 | Ubiquitous | Preeclampsia, nephronophthisis, Parkinson disease |
| SLC41A2 | Ubiquitous | Insulin-dependent diabetes mellitus, Epstein-Barr virus vnfection and Neoplasia |
| Mitochondrial RNA splicing 2 Mrs2 | Ubiquitous | Large congenital melanocytic mevus and Osteopetrosis |
| Paracellin-1 | Ascending limb of loop of Henle | Familial hypomagnesemia with hypercalciuria and nephrocalcinosis |
| Mg2 + transporter 1 MagT1 | Ubiquitous | X-linked Mg2 + deficiency with Epstein-Barr virus infection and neoplasia |