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Schematic diagram of the pro-posed model of Hippo-YAP/TAZ signaling pathway in LECs. The Hippo pathway is a kinase cascade involving MST1/2 mediated activation of LATS1/2 and LATS1/2 mediated inactivation of YAP/TAZ through phosphorylation. Multiple stimulations including VEGF-C, mechanical stress, cell density, and cell polarity may suppress upstream kinases to activate YAP/TAZ transcriptional activity.
