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. 2021 Jun 30;54(6):285–294. doi: 10.5483/BMBRep.2021.54.6.020

Fig. 2.

Fig. 2

Schematic representation of the molecular mechanisms controlling lymphatic specification and sprouting. PROX1 is a key transcription factor that drives lymphatic cell fate specification. Lymphatic endothelial progenitor cells expressing PROX1 arise from the cardinal veins (CV) and intersomitic veins. After specification, LECs migrate out from the CV in a VEGF-C/VEGFR3 dependent manner and form lymph sac. Hippo-YAP/TAZ signaling regulates PROX1 expression during LEC specification and sprouting.