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. 2021 May 3;42(11):3470–3480. doi: 10.1002/hbm.25446

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© 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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The mediation pathways among rs76119478, cuneus morphometry, and working memory. (a) Regional Manhattan plots of genome‐wide association study of left cuneus volume in UKB GWAS summary statistics are generated based on website http://locuszoom.org/ with linkage disequilibrium from 1000 Genomes Project Phase 3 EUR subjects. The identified variant rs76119478 is located at the intergene region and is nearest to the DAMM1 gene. (b) A linear mixed model‐based mediation analysis is used to test the mediation pathways from rs76119478 polymorphism, left cuneus volume, and 2‐back accuracy. A bias‐corrected and accelerated (BCa) bootstrap confidence interval (CI) is used to represent the statistical significance. Values in parentheses indicate the 95% BCa CI. Black values indicate significance under 95% BCa CI