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. 2021 May 3;42(11):3470–3480. doi: 10.1002/hbm.25446

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© 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Association and mediation analysis based on Caucasian sub‐population of HCP dataset. (a) The scatter plot of the association between 2‐back accuracy and left cuneus volume using a linear mixed model (LMM). (b) LMM‐based mediation analysis is used to test the pathways among rs76119478 polymorphism, left cuneus volume, and working memory performance. A bias‐corrected and accelerated (BCa) bootstrap confidence interval (CI) is used to test the significance. Values in parentheses indicate the 95% BCa CI. Black values indicate significance under 95% BCa CI