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. 2021 Jun 22;10(6):bio058807. doi: 10.1242/bio.058807

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© 2021. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — TEX14 protein gradually accumulates on RacGAP-positive bridges during germline cyst formation. (A–A″) In E12.5 ovaries, some RacGAP-positive bridges are TEX14 negative (arrows). (B–B″) A cross section of an E12.5 bridge showing TEX14 protein distributed partially on the RacGAP-positive bridge. (C–C″) A lateral section of an E12.5 bridge showing RacGAP protein located at the outer layer of the bridge and TEX14 located at the inner layer of the bridge. (D–D″) A cross section of an E14.5 bridge showing TEX14 protein completely overlapped with RacGAP protein on the bridge. (E–E″) A longitudinal section of an E14.5 bridge showing TEX14 located at the outer layer and RacGAP located at the inner layer of the bridge. N=6 ovaries (approximately 200 bridges per ovary) were analyzed at each time point. (F,G) A few RacGAP-positive bridges (arrows) were found in E12.5 and E14.5 Tex14 homo mutant ovaries. (H) A diagram showing the process of bridge stabilization via TEX14 accumulation on the bridge and the change in its location to the outer layer of the bridge. (I) A diagram demonstrating defects in germ cell connectivity and oocyte differentiation in Tex14 homo mutant ovaries.