Figure 1.

Types of stress-induced transcription patterns.

(a) Transcriptional memory can manifest itself as stress-induced sustained induction (depicted here) or repression of gene expression that significantly exceeds the duration of the stress cue. (b) Another type of transcriptional memory describes modified gene expression upon repeated exposure to similar stress cues. Depicted here is enhanced re-induction where a gene is induced to higher levels upon the second compared to the first stress exposure. All four combinations of sequential induction/repression exist. (c) In non-memory transcription transient induction (depicted here) or repression of gene expression occurs regardless of a previous stress cue to a similar degree upon repeated stress exposure. Red bars represent stress cues.