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. 2021 Jun 22;24(3):330–343. doi: 10.4048/jbc.2021.24.e32

Figure 5. NORAD sponges miR-155-5p to elevate SOCS1 expression.

Figure 5

(A) StarBase database was used to examine binding site for miR-155-5p in the SOCS1 3′-UTR. (B) StarBase database was used to analyze the relationship between the overall survival of patients with BC and SOCS1 expression. qRT-PCR (C) and western blotting (D) were performed to analyze SOCS1 expression in BC following NORAD and miR-155-5p regulation.

NORAD = non-coding RNA activated by DNA damage; miR = microRNA; SOCS1 = suppressor of cytokine signaling 1; UTR = untranslated region; BC = breast cancer; qRT-PCR = quantitative real-time polymerase chain reaction; GAPDH = glyceraldehyde 3-phosphate dehydrogenase.

*p < 0.001.