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. 2021 Jun 22;24(3):330–343. doi: 10.4048/jbc.2021.24.e32

Figure 6. NORAD counteracts the effects of miR-155-5p in BC cells.

Figure 6

(A) HCC70 cells were transfected with control miRNA, miR-155-5p mimics, miR-155-5p mimics + NORAD overexpression plasmid, or miR-155-5p mimics + SOCS1 overexpression plasmid. MCF-7 cells were transfected with miRNA inhibitor control, miR-155-5p inhibitors, miR-155-5p inhibitors + NORAD siRNA, or miR-155-5p inhibitors + SOCS1 siRNA. Then, qRT-PCR was used to analyze the expression of miR-155-5p in each group of cells. (B) CCK-8, (C) BrdU, and (D) Transwell assays were conducted to analyze proliferation, migration, and invasion of BC cells.

NORAD = non-coding RNA activated by DNA damage; miR = microRNA; BC = breast cancer; siRNA = small interfering RNA; SOCS1 = suppressor of cytokine signaling 1; qRT-PCR = quantitative real-time polymerase chain reaction; CCK-8 = cell counting kit-8.

*p < 0.05, †p < 0.01, and ‡p < 0.001.