Table 3.
Selected characteristics of participants in the Chinese Cervical Cancer Clinical Study.
| Characteristics | Overall (N = 63 926) | The First stage (N = 46 205) | The second stage (N=17 721) | |
|---|---|---|---|---|
| RRH Data (N = 2790) | General data (N = 14 931) | |||
| Age at first diagnosis, years | 49.19 (10.44) | 49.34 (10.55) | 48.12 (10.05) | 48.93 (10.12) |
| Age at first diagnosis, years | ||||
| ≤45 | 24413 (38.19) | 17586 (38.06) | 1117 (40.04) | 5710 (38.25) |
| 46-69 | 37060 (57.97) | 26642 (57.66) | 1636 (58.64) | 8782 (58.82) |
| ≥70 | 2190 (3.43) | 1768 (3.83) | 37 (1.33) | 385 (2.58) |
| Missing | 263 (0.41) | 209 (0.45) | 0 | 54 (0.36) |
| Year of diagnosis | ||||
| 2004-2006 | 4662 (7.3) | 3891 (8.4) | 25 (0.9) | 746 (5.0) |
| 2007-2010 | 13685 (21.4) | 11585 (25.1) | 62 (2.2) | 2038 (13.7) |
| 2011-2014 | 24972 (39.1) | 20886 (45.2) | 650 (23.3) | 3436 (23.0) |
| 2015-2018 | 20599 (32.2) | 9843 (21.3) | 2053 (73.6) | 8703 (58.3) |
| Marital status | ||||
| Married | 61002 (95.43) | 43757 (94.70) | 2667 (95.59) | 14578 (97.64) |
| Unmarried | 306 (0.48) | 226 (0.49) | 23 (0.82) | 57 (0.38) |
| Divorced | 684 (1.07) | 512 (1.11) | 50 (1.79) | 122 (0.82) |
| Widowed | 671 (1.05) | 529 (1.14) | 39 (1.40) | 103 (0.60) |
| Remarried | 231 (0.36) | 200 (0.43) | 11 (0.39) | 20 (0.13) |
| Unknown | 1032 (1.61) | 981 (2.12) | 0 | 51 (0.34) |
| Residence | ||||
| Rural | 37626 (58.86) | 26791 (57.98) | 1422 (51.00) | 9413 (63.00) |
| Urban | 18419 (28.81) | 12782 (27.66) | 1027 (36.80) | 4610 (30.90) |
| Unknow | 7881 (12.33) | 6632 (14.35) | 341 (12.20) | 908 (6.10) |
| Region | ||||
| North | 19653 (30.7) | 18410 (39.8) | 400 (14.3) | 843 (5.60) |
| South | 10889 (17.0) | 10633 (23.0) | 256 (9.2) | 0 |
| Central | 11571 (18.1) | 7092 (15.3) | 306 (11.0) | 4173 (27.9) |
| East | 7305 (11.4) | 4563 (9.9) | 0 | 2742 (18.4) |
| Southwest | 5865 (9.2) | 5507 (11.9) | 0 | 358 (2.4) |
| Northwest | 6499 (10.2) | 0 | 1828 (65.5) | 4671 (31.3) |
| Northeast | 2144 (3.4) | 0 | 0 | 2144 (14.4) |
| City scale | ||||
| First-tier | 8948 (14.0) | 8548 (18.5) | 400 (14.3) | 0 |
| Second-tier | 44929 (70.3) | 29006 (62.8) | 2310 (82.8) | 13613 (91.2) |
| Third-tier and below | 10049 (15.7) | 8651 (18.7) | 80 (2.90) | 1318 (8.8) |
| Institution type | ||||
| General hospital | 31997 (50.1) | 16000 (34.6) | 2534 (90.8) | 13463 (90.2) |
| Cancer center | 29893 (46.8) | 28425 (61.5) | 0 | 1468 (9.8) |
| Women and children center | 2036 (3.2) | 1780 (3.9) | 256 (9.2) | 0 |
| Delivery types | ||||
| No delivery | 624 (0.98) | 529 (1.14) | 38 (1.36) | 57 (0.38) |
| Vaginal delivery | 50864 (79.57) | 35449 (76.72) | 2332 (83.58) | 13083 (87.62) |
| Cesarean delivery | 2669 (4.18) | 1643 (3.56) | 229 (8.21) | 797 (5.34) |
| Vaginal and cesarean delivery | 822 (1.29) | 524 (1.13) | 71 (2.54) | 227 (1.52) |
| Unknown | 8947 (14.00) | 8060 (17.44) | 120 (4.30) | 767 (5.14) |
| FIGO stage (2009) | ||||
| IA1 | 2496 (3.90) | 1657 (1.07) | 105 (3.76) | 734 (4.92) |
| IA2 | 714 (1.12) | 496 (27.83) | 42 (1.51) | 176 (1.18) |
| IB1 | 18036 (28.21) | 12858 (7.92) | 1182 (42.37) | 3996 (26.76) |
| IB2 | 4716 (7.38) | 3660 (1.54) | 231 (8.28) | 825 (5.53) |
| IA | 1056 (1.65) | 713 (1.26) | 36 (1.28) | 307 (2.06) |
| IB | 928 (1.45) | 581 (11.86) | 30 (1.08) | 317 (2.12) |
| IIA1 | 7702 (12.05) | 5479 (6.40) | 471 (16.88) | 1752 (11.73) |
| IIA2 | 3901 (6.10) | 2956 (2.32) | 211 (7.56) | 734 (4.92) |
| IIA | 1455 (2.28) | 1071 (12.40) | 26 (0.93) | 358 (2.40) |
| IIB | 8542 (13.36) | 5729 (1.25) | 302 (10.82) | 2511 (16.82) |
| IIIA | 772 (1.21) | 576 (8.30) | 17 (0.61) | 179 (1.20) |
| IIIB | 4680 (7.32) | 3833 (0.28) | 25 (0.90) | 822 (5.51) |
| I | 177 (0.28) | 129 (0.23) | 0 | 48 (0.32) |
| II | 129 (0.20) | 108 (0.41) | 3 (0.11) | 18 (0.12) |
| III | 211 (0.33) | 188 (0.25) | 1 (0.04) | 22 (0.15) |
| IVA | 145 (0.23) | 115 (0.49) | 2 (0.07) | 28 (0.19) |
| IVB | 241 (0.38) | 228 (0.47) | 1 (0.04) | 12 (1.08) |
| IV | 303 (0.47) | 217 (1.38) | 0 | 86 (0.58) |
| CIN | 987 (1.54) | 637 (10.77) | 7 (0.25) | 343 (2.30) |
| Unknown | 6735 (10.54) | 4974 (10.54) | 98 (3.51) | 1663 (11.14) |
| Gross type | ||||
| Erosion | 809 (1.3) | 809 (1.8) | 0 | 0 |
| Exophytic | 26630 (41.7) | 19154 (41.5) | 1479 (53.0) | 5997 (40.2) |
| Endophytic | 5951 (9.3) | 4993 (10.8) | 98 (3.5) | 860 (5.8) |
| ulcerative | 7487 (11.7) | 6686 (14.5) | 115 (4.1) | 686 (4.6) |
| Cervical canal | 776 (1.2) | 551 (1.2) | 109 (3.9) | 116 (0.8) |
| After conization | 2047 (3.2) | 1276 (2.8) | 111 (4.0) | 660 (4.4) |
| No found | 16347 (25.6) | 11130 (24.1) | 785 (28.1) | 4432 (29.7) |
| Unknown | 3879 (6.1) | 1606 (1.8) | 93 (3.3) | 2180 (14.6) |
| pathological tumor type | ||||
| Squamous cell carcinoma | 56141 (87.8) | 40612 (87.9) | 2455 (88.0) | 13074 (87.6) |
| Adenocarcinoma | 4422 (6.9) | 3037 (6.6) | 243 (8.7) | 1142 (7.8) |
| Adenosquamous carcinoma | 992 (1.6) | 757 (1.6) | 43 (1.5) | 192 (1.3) |
| Clear cell carcinoma | 117 (0.2) | 90 (0.2) | 4 (0.1) | 23 (0.2) |
| Small cell neuroendocrine carcinoma | 372 (0.6) | 279 (0.6) | 1 (0.0) | 92 (0.6) |
| Other subtypes | 518 (0.8) | 376 (0.8) | 29 (1.0) | 113 (0.8) |
| Unknown | 1364 (2.1) | 1054 (2.3) | 15 (0.5) | 295 (2.0) |
FIGO, the International Federation of Gynecology and Obstetrics; CIN, cervical intraepithelial neoplasia.