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. 2021 Jun 18;11:702510. doi: 10.3389/fonc.2021.702510

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Copyright © 2021 Deng, Cai, Shen and Peng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tetraspanins that promote gastric cancer cell proliferation and invasion. CD151, TSPAN8, TSPAN4, and TSPAN1 interact with other biomolecules in TEMs to facilitate the growth and invasion of gastric cancer cells. Especially, CD151 forms a complex with integrin α3, and on the other hand, PVT1 could bind to miR-152 to inhibit the expression of miR-152 to promote gastric cancer cell growth. TSPAN8 regulates gastric cancer cell proliferation via mediating the effect of EGF and activating the ERK MAPK pathway.