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. 2021 Jun 18;11:702510. doi: 10.3389/fonc.2021.702510

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Copyright © 2021 Deng, Cai, Shen and Peng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tetraspanins that suppress gastric cancer cell proliferation and lead to apoptosis. CD81 acts as a pro-apoptotic effector through inducing a G1 cell cycle arrest and inhibiting the phosphorylation of p38 MAPK. CD82 suppresses the EGFR/ERK1/2-MMP7 signaling pathway to represses gastric cancer invasion. TSPAN9 inhibits the ERK1/2 pathway to downregulate the expression of MMP-9 and uPA and inhibits the FAK-RAS-ERK1/2 signal pathway to repress invasion of gastric cancer cells. TSPAN5 suppresses the tumor proliferation via increasing the expression of p27/p15 and decreasing the expression of cyclin D1, CDK4, pRB, and E2F1 to control cell cycle transition.