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Schematic representation of regulation of the PI3K/Akt and Wnt/β-catenin pathways involved in cancer progression by NLRC5 (1) NLRC5 promotes HCC progression via the AKT/VEGF-A signaling pathway. (2) NLRC5 mediates cell proliferation, invasion, and migration in HCC and ccRCC by activating c-Myc and cyclin D1, the key target genes of the Wnt/β-catenin signaling pathway.
