FIGURE 5.

Tissue‐specific alveolar‐epithelial Sdha deletion mediates lung protection during ALI: A‐E, Sdha^loxp/loxp SPC‐CreER mice or age, gender, and weight‐matched controls (SPC‐CreER) were exposed PIP of 45 cm H₂O to induce lung injury or control ventilation (15 cm H₂O). A and B, mRNA expression was determined from ATII cells with qPCR. C, Protein concentration was measured in bronchoalveolar lavage fluid (BALF). D, Representative images of H&E‐stained lungs from mice subjected to PIP of 15 vs 45 cm H₂O. E, Cumulative lung injury score which is a combined score of cellular infiltrates, interstitial congestion and hyaline membrane formation, and hemorrhage. Data are represented as mean ± SD, n = 4‐7, ns‐not significant, *P <.05, **P <.01. Welch's t test with Bonferroni adjustment. Total of 35 animals were used