TABLE 7.
Predictors of torsade de pointes
| Risk factor | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| P value | OR | 95% CI | P value | OR | 95% CI | |
| Non‐ischemic heart disease | .012 | 4.66 | 1.24‐17.40 | |||
| Coronary artery disease | .068 | 3.38 | 0.84‐13.6 | |||
| Heart failure | .004 | 6.00 | 1.50‐24.4 | |||
| Chronic kidney disease | .003 | 6.40 | 1.60‐26.0 | |||
| Chronic liver disease | <.001 | 19.5 | 2.30‐165.8 | |||
| Lopinavir‐ritonavir | .080 | 3.05 | 0.82‐11.40 | .006 | 8.2 | 1.84‐36.0 |
| Azithromycin coadministration | .012 | 0.58 | 0.57‐0.60 | |||
| Furosemide | <.001 | 9.08 | 2.40‐34.0 | .030 | 4.83 | 1.16‐20.0 |
| Metolazone | <.001 | 36.6 | 4.10‐328.4 | .028 | 34.7 | 1.46‐826 |
| QT prolonging drugs | .021 | 4.47 | 1.11‐18.0 | |||
| Amiodarone | <.001 | 31.3 | 7.54‐130.0 | .002 | 14.5 | 2.74‐77.0 |
| Hypokalaemia | <.001 | 8.40 | 2.10‐34.0 | .006 | 8.50 | 1.84‐39.3 |
| Hypocalcaemia | .025 | 4.03 | 1.07‐15.0 | |||
| Acute renal dysfunction | .040 | 3.60 | 0.97‐13.6 | |||
| QTc ≥ 500 ms | .036 | 3.97 | 0.99‐16.0 | |||
| ∆QT ≥ 60 ms | <.001 | 9.46 | 2.36‐38.0 | |||
Abbreviations: CI, confidence interval; OR, odds ratio.