TABLE 2.
Severe acute respiratory syndrome coronavirus 2 viral kinetics and disease course among 28 transplantation and cellular therapy patients with coronavirus disease 2019
| Patient | Age/gender | T‐cell therapy | Symptoms at presentation | Initial Ct value a | Viral shedding b (d) | Clearance (d) | Severity c | Oxygen requirement c | Hospital admission | ICU admission | Shock | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 32/F | Allogeneic | Fever, cough, SOB, myalgia, fatigue, HA, N/V, chills | NA | 20 | 34 | Mild | 0 | No | No | No | Alive |
| 2 | 68/M | Allogeneic | Fever, cough, SOB, fatigue, chills | NA | 14 | NA | Critical | MV | Yes | Yes | Yes | Death (28 d after diagnosis) |
| 3 | 54/M | Allogeneic | Fever, myalgia, fatigue, diarrhea, N/V, chills, abdominal pain | NA | NA | NA | Critical | BiPAP | Yes | Yes | Yes | Death (116 d after diagnosis) |
| 4 d | 62/F | Allogeneic | HA | NA | NA | NA | Mild | NA | Yes | No | No | Alive |
| 5 | 40/F | Allogeneic | Fever, cough, SOB, myalgia, HA, N/V, chills, anosmia, nasal congestion | 11.6 | 25 | NA | Mild | 0 | Yes | No | No | Alive |
| 6 | 65/M | Allogeneic | Fever, cough, SOB, HA | NA | 37 | 44 | Severe | HFNC | Yes | No | No | Alive |
| 7 | 57/F | Allogeneic | Asymptomatic | NA | NA | NA | Mild | 0 | No | No | No | Alive |
| 8 | 40/F | Allogeneic | Anosmia | NA | NA | NA | Mild | 0 | No | No | No | Alive |
| 9 | 55/M | Allogeneic | Cough, N/V, anosmia | NA | NA | NA | Mild | 0 | No | No | No | Alive |
| 10 | 72/M | Allogeneic | Cough | NA | 28 | 49 | Moderate | NC, 2 L | Yes | No | No | Alive |
| 11 | 75/M | Allogeneic | Fever, cough, sore throat | NA | 21 | NA | Mild | 0 | No | No | No | Alive |
| 12 | 52/F | Allogeneic | Fever, cough, chills | 19.2 | 7 | NA | Critical | MV | Yes | Yes | Yes | Death (22 d after diagnosis) |
| 13 | 55/M | Allogeneic | Fever, cough, SOB, myalgia, fatigue, diarrhea, chills | NA | NA | NA | Critical | MV | Yes | Yes | Yes | Death (16 d after diagnosis) |
| 14 | 49/M | Allogeneic | Fever, cough, SOB | NA | NA | 24 | Moderate | NC, 2 L | Yes | No | No | Alive |
| 15 | 50/F | Allogeneic | Asymptomatic | NA | NA | NA | Mild | 0 | No | No | No | Alive |
| 16 | 32/M | Autologous | Asymptomatic at presentation—then developed anosmia | NA | 12 | NA | Mild | 0 | No | No | No | Alive |
| 17 | 72/F | Autologous | Fever | NA | 64 | 36 | Moderate | 0 | Yes | No | No | Alive |
| 18 | 63/M | Autologous | Fever, SOB | NA | NA | 34 | Severe | NC, 5 L | Yes | No | No | Alive |
| 19 | 67/F | Autologous | Fever, chills | 31.4 | 35 | NA | Critical | MV | Yes | Yes | Yes | Death (38 d after diagnosis) |
| 20 | 44/M | Autologous | Fever, cough, fatigue | NA | NA | NA | Moderate | 0 | No | No | No | Alive |
| 21 | 71/F | Autologous | SOB | 23.6 | 37 | 56 | Critical | MV | Yes | Yes | Yes | Death (81 d after diagnosis) |
| 22 | 68/M | Autologous | Asymptomatic | 34.5 | NA | 21 | Mild | 0 | No | No | No | Alive |
| 23 | 66/F | Autologous | Fever, fatigue | 14 | NA | NA | Critical | MV | Yes | Yes | Yes | Death (21 d after diagnosis) |
| 24 | 57/M | Autologous | Fever, cough | 24.1 | 20 | NA | Mild | 0 | No | No | No | Alive |
| 25 | 51/M | Autologous | Fever | NA | NA | 31 | Moderate | 0 | No | No | No | Alive |
| 26 | 43/M | Autologous | Asymptomatic | NA | 26 | NA | Mild | 0 | No | No | No | Alive |
| 27 | 64/F | Autologous | Fever | 24.4 | NA | NA | Moderate | 0 | Yes | No | No | Alive |
| 28 | 67/M | CAR‐T | Cough, fatigue, anosmia | 22 | 26 | NA | Severe | NC, 5 L | Yes | No | No | Alive |
Abbreviations: BiPAP, bilevel positive airway pressure; CAR‐T, chimeric antigen receptor T‐cell therapy; Ct, cycle threshold; HA, headache; HFNC, high flow nasal cannula; ICU, intensive care unit; MV, mechanical ventilation; N/V, nausea/vomit; NA, not available; NC, nasal cannula; SOB, shortness of breath.
a
Ct values for S (encoding the structural spike glycoprotein) gene target using Simplexa® (DiaSorin molecular) polymerase chain reaction platform.
b
Refer to Section 2 in main text for definition.
c
At maximum point of illness.
d
Diagnosed at outside hospital.