TABLE 1.
Baseline demographics and clinical features prior to admission for COVID‐19 versus other respiratory viral illness cohorts
| COVID‐19 N = 443 |
ORVI N = 387 |
p | |
|---|---|---|---|
| Age (y), median (IQR) | 66 (55−75) | 64 (55−75) | .28 |
| Female, N (%) | 192 (43.3) | 189 (48.8) | .11 |
| Race, N (%) | |||
| White | 148 (34.3) | 173 (46.5) | <.001 |
| Black | 234 (54.3) | 173 (46.5) | |
| Asian or Pacific islander | 32 (7.4) | 11 (3.0) | |
| Other | 17 (3.9) | 15 (4.0) | |
| Unknown/missing | 12 (.) | 15 (.) | |
| Hispanic/Latino ethnicity, N (%) | 46 (10.6) | 8 (2.1) | <.001 |
| Body mass index, mean (SD) | 31.3 (9.6) | 29.2 (9.6) | .002 |
| Coronary artery diseasea, N (%) | 56 (12.6) | 55 (14.3) | .49 |
| Hypertensiona, N (%) | 295 (72.0) | 221 (60.5) | <.001 |
| Dyslipidemiaa, N (%) | 176 (44.1) | 108 (29.8) | <.001 |
| Diabetesa, N (%) | 166 (37.5) | 102 (26.5) | <.001 |
| Heart failurea, N (%) | 57 (12.9) | 76 (19.7) | .007 |
| Presence of left ventricular assist devicea, N (%) | 1 (0.2) | 1 (0.3) | .92 |
| Strokea, N (%) | 46 (10.4) | 31 (8.1) | .28 |
| Chronic lung diseasea, N (%) | 100 (22.6) | 178 (46.2) | <.001 |
| Chronic liver diseasea, N (%) | 9 (2.0) | 6 (1.6) | .80 |
| Chronic kidney diseasea, N (%) | 42 (9.5) | 30 (7.8) | .46 |
| End stage renal disease on dialysisa, N (%) | 14 (3.2) | 14 (3.6) | .71 |
| History of prior or current malignancya, N (%) | 71 (16.0) | 113 (29.4) | <.001 |
| Organ transplant recipienta, N (%) | 3 (0.7) | 30 (7.8) | <.001 |
| Smoking (any), N (%) | 160 (36.1) | 235 (60.7) | <.001 |
| Active, N (%) | 19 (4.2) | 56 (14.4) | |
| Former, N (%) | 141 (31.8) | 179 (46.2) | |
| Missing, N (%) | 73 (16.5) | 24 (6.2) | |
| Charlson Comorbidity Indexb, mean (SD) | 1.2 (1.85) | 1.9 (2.18) | <.001 |
| Use of anticoagulant prior to hospitalization, N (%) | 64 (14.4) | 87 (22.5) | .003 |
| Indication for anticoagulant use before hospitalizationc, N (%) | |||
| None | 379 (85.6) | 300 (77.5) | .003 |
| Prior venous thromboembolism | 28 (6.3) | 34 (8.8) | .18 |
| Atrial fibrillation or flutter | 29 (6.5) | 45 (11.6) | .01 |
| Mechanical or bioprosthetic valve | 0 | 1 (0.3) | .47 |
| Prior stroke | 3 (0.7) | 5 (1.3) | .48 |
| Other indication | 9 (2.0) | 10 (2.6) | .60 |
Abbreviations: COVID‐19, coronavirus disease 2019; IQR, interquartile range; ORVI, other respiratory virus infection; SD, standard deviation.
a
Presence of medical condition noted in encounter before index hospitalization admission date. In patients without prior encounters, initial admission note was reviewed for presence of the medical condition.
b
Calculated from International Classification of Diseases‐10 codes from any encounters before admission.
c
Patients could have more than one indication for anticoagulation.