Table 2.
Univariate (non-adjusted) and adjusted competing risk analyses for the association of acute graft-versus-host disease with relevant microbiota variables.
| Adjusted | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Non-adjusted | Veillonella at P | Streptococcus at P | Corynebacterium at P | Ratio at P | E.faecalis bloom | |||||||
| HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Graft source (Bone Marrow) | 0.95 (0.35-2.63) | 0.92 | 1.42 (0.43-9.03) | 0.38 | 0.75 (0.23-2.46) | 0.64 | 1.42 (0.40-5.04) | 0.59 | 0.78 (0.25-2.46) | 0.67 | 1.63 (0.42-6.35) | 0.49 |
| Conditioning intensity (Myeloablative) | 0.74 (0.26-2.17) | 0.59 | 0.50 (0.11-2.32) | 0.37 | 0.79 (0.24-2.61) | 0.7 | 0.79 (0.20-3.04) | 0.73 | 0.92 (0.27-3.16) | 0.89 | 0.94 (0.24-3.61) | 0.92 |
| Diversity (Shannon) at P (High vs. Low) | 0.68 (0.26-1.78) | 0.43 | – | – | – | – | – | – | – | – | – | – |
| Diversity (Shannon) at A (High vs. Low) | 0.88 (0.33-2.31) | 0.79 | – | – | – | – | – | – | – | – | – | – |
| Diversity (Shannon) at E (High vs. Low) | 0.92 (0.33-2.58) | 0.87 | – | – | – | – | – | – | – | – | – | – |
| Veillonella at P (High vs. Low) | 0.24 (0.08-0.70) | 0.009 | 0.21 (0.07-0.65) | 0.006 | – | – | – | – | – | – | – | – |
| Streptococcus at P (High vs. Low) | 2.89 (1.07-7.79) | 0.036 | – | – | 3.17 (1.12–9.01) | 0.03 | – | – | – | – | – | – |
| Corynebacterium at P (High vs. Low) | 2.74 (1.05-7.15) | 0.04 | – | – | – | – | 2.79 (0.99-7.9) | 0.053 | – | – | – | – |
| Ratio at P (>1 vs. ≤1) | 0.23 (0.08-0.62) | 0.004 | – | – | – | – | – | – | 0.22 (0.08-0.64) | 0.005 | – | – |
| Ratio at A (>1 vs. ≤1) | 0.45 (0.16-1.23) | 0.12 | – | – | – | – | – | – | – | – | – | – |
| Ratio at E (>1 vs. ≤1) | 0.73 (0.27-1.98) | 0.54 | – | – | – | – | – | – | – | – | – | – |
| Any genus bloom (Yes vs. No) | 2.29 (0.63-2.36) | 0.21 | – | – | – | – | – | – | – | – | – | – |
| E. faecalis bloom (Yes vs. No) | 4.07 (1.82-9.14) | 0.0007 | – | – | – | – | – | – | – | – | 4.90 (1.66-14.5) | 0.004 |
Each multivariate model adjusts for graft source and conditioning intensity. Statistically significant associations are marked in bold. HR, Hazard ratio; CI, Confidence interval; P, preconditioning; A, aplasia; E, engraftment.