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. 2021 Jun 18;15:706713. doi: 10.3389/fnint.2021.706713

Figure 1.

Figure 1

The PVT as a critical node of the hypothalamic-thalamic-striatal circuit. This graphic illustrates the afferents and efferents associated with the paraventricular nucleus of the thalamus (PVT), with an emphasis on the hypothalamic-thalamic-striatal circuit. The purple neuron represents orexinergic (OX) innervation from the lateral hypothalamus (LH)-PVT. The orange neuron is illustrating glutamatergic (Glu) innervation from the PVT-nucleus accumbens (NAc). The blue circle depicts the NAc, which receives substantial innervation from the PVT. The gray circle represents the anatomical location of the prelimbic cortex (PrL), which sends dense glutamatergic innervation to the PVT. The dotted black lines throughout the schematic depict neuronal connections, some of which are reciprocal (double arrow). Amy, amygdala; BNST, bed nucleus of the stria terminalis; DR, dorsal raphe; Hipp, hippocampus; IL, infralimbic cortex; LH, lateral hypothalamus; NAc, nucleus accumbens; PAG, periaqueductal gray; PrL, prelimbic cortex; PVT, paraventricular thalamic nucleus; SCN, suprachiasmatic nucleus; VP, ventral pallidum; VTA, ventral tegmental area; DA, dopamine; Glu, glutamate; OX, orexin.