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Potential origins of spindle cells from endothelial and mesenchymal cells. KSHV infection may lead to de-differentiation of both endothelial and mesenchymal cells through endothelial-to-mesenchymal (EndMT) and mesenchymal-to-endothelial transition (MEndT), respectively. The infected cells thus because more motile, angiogenic and proliferative. Nonetheless, paracrine signals are likely needed for full transformation of the cells.
