Table 1.
Patient characteristics of the included studies
| Study, year | Country | Study design | Patients, n | Mean age (SD) | Gender, M/F | Duration of RT‐PCR positivity, days, mean (SD) | Viral culture | sg‐RNA | Serology (n) | Severe patientsa (n) | Outcome (n) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Avanzato et al., 2020 7 | USA | Case report | 1 | 71 | F | 105 | Positive (Day 70) | Positive (Day 105) | NR | 0 | Recovered |
| Aydillo et al., 2020 3 | USA | Retrospective | 20 | 58.5 (10.5) | 11/9 | 49 (20.2) | Positive (mean, 27.4 days, 5 patients) | NR | Positive (7), negative (8) | 11 | Recovered (16), died (4) |
| Baang, 2021 13 | USA | Case report | 1 | 60 | M | 131 | Positive (Days 7, 12, 22, 29, 33, 38, 93, 106, and 119) | NR | Positive (Day 60 and 88) | 1 | Recovered |
| Choi, 2020 14 | USA | Case report | 1 | 45 | M | 151 | Positive (Days 75 and 143) | NR | Positive (IgG and IgM) at Days 81 and 87 | 1 | Died |
| Clark, 2020 | France | Case report | 1 | 76 | F | 57 | NR | NR | Negative | 1 | Recovered |
| Daniel, 2020 | Lebanon | Case report | 1 | 55 | M | 76 | NR | NR | Negative | 0 | Recovered |
| Decker, 2020 15 | Germany | Case report | 1 | 62 | M | 35 | Positive (Days 18 and 21) | NR | NR | 0 | Recovered |
| Desmazes‐Dufeu, 2020 | France | Case series | 2 | 37 (4.2) | 1/1 | 25 (21.2) | NR | NR | NR | 1 | Recovered (2) |
| Italiano, 2020 | USA | Case report | 1 | 20 | F | 42 | NR | NR | Positive (IgG) at Day 35 | 0 | Recovered |
| Karatas, 2020 | Turkey | Case report | 1 | 61 | M | 74 | NR | NR | NR | 0 | Recovered |
| Menghua, 2020 | China | Case report | 1 | 45 | F | 35 | NR | NR | Positive (IgM) at Day 35 | 0 | Recovered |
| Mingyao Ma, 2020 | Hong Kong | Case report | 1 | 31 | F | 38 | NR | NR | Negative | 0 | Recovered |
| Moore, 2020 | USA | Case report | 1 | 63 | F | 74 | NR | NR | Negative (Day 90) | 1 | Recovered |
| Nakajima, 2020 | Japan | Case report | 1 | 47 | M | 65 | NR | NR | Negative (Day 82) | 1 | Recovered |
| Niess, 2020 | Germany | Case report | 1 | 56 | M | 31 | Negative (Day 49) | NR | Positive (IgG) at Day 21 | 0 | Recovered |
| Rodriguez‐Grande et al., 2020 8 | Spain | Retrospective | 7 | 56.3 (12.9) | 4/3 | 64.1 (19.5) | NR | Positive (mean, 51.1 days, 7 patients) | Positive (3), negative (2) | 4 | Recovered (5), Died (2) |
| Wei, 2020 | China | Case report | 1 | 61 | M | 52 | NR | NR | Positive (IgG) at Day 41 | 0 | Recovered |
| Wu, 2020 | China | Retrospective | 14 | 36.5 | 9/5 | 26.2 (6.7) | NR | NR | Positive (IgG) (3) with median 36 days, negative (3) | 13 | Recovered (8), died (6) |
| Zhang Man, 2020 | China | Case report | 1 | 49 | M | 65 | NR | NR | Positive (IgG) at day 47 | 0 | Recovered |
| Zhu, 2020 (1) | China | Case report | 1 | 55 | M | 49 | NR | NR | Positive (IgG) at day 49 | 1 | Recovered |
| Zhu et al., 2020 (2) 9 | China | Case series | 10 | 45 | 8/2 | 28.4 (9.3) | NR | NR | NR | 8 | Recovered (9), died (1) |
Abbreviations: F, female; M, male; ICU, intensive care unit; n, sample size; NR, not reported; RT‐PCR, reverse‐transcriptase polymerase chain reaction; sg‐RNA, subgenomic RNA.
a
Respiratory distress (rate ≥ 30/min, oxygen saturation ≤ 93% at rest and/or PaO2/FiO2 ≤ 300 mmHg), ICU admission, and/or death.
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