TABLE 1.
Studies reporting correlation of nAb titer with clinical variables in COVID‐19
| Country (n) | Median nAb titer | Age (AOR) | Male sex (AOR) | Fever during acute illness (AOR) | Clinical severity by WHO ordinal scale (AOR) | Lymphocyte count | ABO blood group | Days since diagnosis | BMI | Ref |
|---|---|---|---|---|---|---|---|---|---|---|
| USA (250) | 60% ≥1:80 | 1.03/year of age | 2.08 | 2.73 | 6.59 | 34 | ||||
| USA (126) | 0.1 every 10 y a | 0.27 a | 0.86 a | −0.192 every 10 d | 41 | |||||
| USA (97) | No correlation | Trend | No correlation | No correlation | 17 | |||||
| USA (221) | No correlation (fever vs. no fever) | Mean titer higher in ICU than in hospitalized higher than in HCW | 26 | |||||||
| USA (47) | Mean titer higher in age 48 to 75 y | No correlation | 18 | |||||||
| Austria (100) | 1:230 | r 2 = .09 | Mean titer 1:60 in females vs. 120 in males | Mean titer 1:208 in WHO scores 1 and 2 vs.1:696 in WHO scores 3 and 4 (rank) | 42 | |||||
| Brazil (149) | A/AB higher than B/O (rank) | >21 (rank) | 33, 43 | |||||||
| China (175) | ID50 RLU | >40 y higher than <40 (ranks) r = 0.4 | r = −.44 | 15 | ||||||
| France (140) | x (ICU) | 25 | ||||||||
| Germany (49) | No | x | 24 | |||||||
| Germany (62) | No | No | Duration and severity | 44 | ||||||
| Italy (494) | 93% >1:80 | 0.26 (linear variable) | −0.14 (linear variable) | 0.28 (linear variable) | No correlation | 20 | ||||
| UK (330) | 1:69 | 1.02 (linear variable) | 2.41 | 2.25 | AB/B higher than A/O (rank) | 0.94 (linear variable) | 16 | |||
| Greece (60) | Age >50 | Hospitalization | No correlation | 45 | ||||||
| China (23) | Mechanical ventilation higher than isolation wards | 46 | ||||||||
| Spain (54) | No difference ICU vs non‐ICU | 47 | ||||||||
| USA (120) | Age >30 | Yes | Yes | BMI >30 |
Abbreviations: AOR, adjusted odds ratio; nAb, neutralizing antibodies; BMI, body mass index; HCW, healthcare workers. x = AOR or correlation coefficient not reported. Empty cells mean the parameter was not investigated in that given study.
a
Linear regression model coefficients.
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