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editorial

. 2021 Apr 18;109(6):1017–1018. doi: 10.1002/JLB.3CE0121-002R

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©2021 Society for Leukocyte Biology

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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SARS-CoV-2 infection in young versus old. Elevated G-CSF and earlier neutrophil release may drive neutrophil pathology in severe COVID-19. In younger individuals, infection recruits mature neutrophils that function and are cleared appropriately. In older individuals, elevated G-CSF results in immature neutrophil release. Infection recruits these cells that may be less functional and thus accumulate and cannot clear as effectively. Infection persists and may drive further neutrophil migration and accumulation