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. 2021 Apr 13;111(1):283–289. doi: 10.1002/JLB.6COVCRA1120-762R

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© 2021 The Authors. Journal of Leukocyte Biology published by Wiley Periodicals LLC on behalf of Society for Leukocyte Biology

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Temporal dynamics of the top 10 clonotypes and Shannon diversity index in severe and critical COVID‐19 patients. No significant differences were observed in the cumulative frequency of the top 10 clonotypes over time between patients with severe (A) and critical (B) disease course. Also, no significant differences were observed in Shannon diversity index of severe (C) and critical (D) COVID‐19 patients. Red lines, derived from linear regression, represent the overall increasing or decreasing trend. The horizontal dashed lines represent the mean cumulative frequency of the top 10 clonotypes in 11 healthy controls, included as a reference. Severe group n = 46, Critical group n = 41.