TABLE 1.
Clinical features of 20 patients with COVID‐19 treated with Chelidonium majus
| Patient | Age (years) | Gender | Symptoms | Changes on physical examination | Comorbidities | Number of days with symptoms before starting Chel. | Number of days until resolution of the clinical features after the introduction of Chel. | Number of days with Chel. | Diagnostic test |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 40 | M | Fever, pruritic erythematous papules, anosmia, dysgeusia, sore throat, coryza, cough, fatigue | Oropharyngeal hyperemia, edema of the nasal turbinates | Overweight | 4 | 2 | 3 | IgM +, IgG + |
| 2 | 38 | F | Fever, dysgeusia, coryza, sore throat, cough, headache | Oropharyngeal hyperemia | No | 10 | 3 | 4 | Nasopharyngeal swab PCR test + |
| 3 | 47 | F | Headache, myalgia, arthralgia, fever, anosmia, ageusia, anorexia, epigastric pain, dry cough, sore throat | Oropharyngeal hyperemia, epigastric pain | Hypertension | 10 | 2 | 3 | Nasopharyngeal swab PCR test + |
| 4 | 42 | F | Anosmia, sore throat, anorexia | Oropharyngeal hyperemia | No | 4 | 3 | 5 | Nasopharyngeal swab PCR test + |
| 5 | 45 | M | Anosmia, fatigue, dyspnea, cough, back pain, headache, arthralgia, fever | Fever | Sickle cell trait | 5 | 7 | 7 | Nasopharyngeal swab PCR test + |
| 6 | 40 | F | Chest pain, coryza, sore throat, cough, headache | Oropharyngeal hyperemia | No | 5 | 3 | 5 | Nasopharyngeal swab PCR test + |
| 7 | 37 | F | Anosmia, ageusia, fever, body aches, dyspnea, fatigue | Oropharyngeal hyperemia | Overweight | 7 | 2 | 5 | No |
| 8 | 37 | M | Fatigue, body aches, headache, anosmia, ageusia | Oropharyngeal hyperemia | Overweight | 8 | 3 | 5 | No |
| 9 | 64 | F | Coryza, sneezing, body aches, malaise, fatigue, dyspepsia, insomnia | Edema of the nasal turbinates | Hypertension | 1 | 2 | 3 | No |
| 10 | 14 | M | Diarrhea, anorexia, nausea, malaise, indisposition in the morning | Diffuse abdominal pain | Overweight | 1 | 1 | 3 | IgM +, IgG ‐ |
| 11 | 53 | F | Fever, fatigue, sore throat, anosmia, anorexia, diarrhea, dyspepsia | Oropharyngeal hyperemia, abdominal pain | Overweight | 4 | 3 | 3 | No |
| 12 | 36 | F | Headache, thoracolumbar pain, fermentative dyspepsia | Intense borborygmus | No | 19 | 3 | 7 | Nasopharyngeal swab PCR test + |
| 13 | 53 | F | Profuse and cold sweating, coryza, sneezing, tearing, fatigue, postural dizziness, dysuria | No | No | 3 | 3 | 7 | Nasopharyngeal swab PCR test + |
| 14 | 45 | F | Coryza, dry cough, chest pain, odynophagia, eructation, fermentative dyspepsia, anorexia, body aches, cooling in the lower limbs, fear of dying | High blood pressure, abdomen distended, slow peristalsis | No | 7 | 5 | 7 | Nasopharyngeal swab PCR test + |
| 15 | 36 | F |
Chest pain, fatigue, tremors, cooling In lower limbs, fear of dying |
No | No | 3 | 5 | 7 | Nasopharyngeal swab PCR test + |
| 16 | 71 | F | Dry cough, odynophagia, fatigue, body aches, dysuria, anorexia | Oropharyngeal hyperemia, breath sounds diminished (apices) | Hypertension, type 2 diabetes | 1 | 5 | 7 | IgM +, IgG ‐ |
| 17 | 28 | F | Fatigue, malaise | No | No | 5 | 5 | 7 | IgM +, IgG ‐ |
| 18 | 61 | F | Fever, headache, anosmia, ageusia, odynophagia, fatigue, anorexia | Oropharyngeal hyperemia, fever | No | 1 | 9 | 12 | IgM ‐, IgG + |
| 19 | 59 | F | Headache, coryza, odynophagia, body aches, fatigue, fever | Oropharyngeal hyperemia, fever | No | 1 | 7 | 8 | Nasopharyngeal swab PCR test + |
| 20 | 34 | F | Dry cough, dyspnea, odynophagia, myalgia, fever | No | Chronic bronchitis | 4 | 3 | 5 | Nasopharyngeal swab PCR test + |
Note: Chel. = Chelidonium majus; F: female; M: male; +: positive; −: negative.