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. 2021 Jun 18;12:678330. doi: 10.3389/fmicb.2021.678330

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Copyright © 2021 Chen, Chen, Yang, Kuo, Jan, Yang, Hsieh, Lee, Lin and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of amino acid substitutions and different N-terminus modifications on the antimicrobial activity and hemolytic activity of the AMPs. Upper panel: changing hydrophobic and positively charged residues; middle panel: using different fatty acyl modifications and D-amino acids; lower panel: using short chain-acyl groups for N-terminal modification. (A,C,E) The MIC and MBC values against A. baumannii 17978 displayed as a violin plot. Each concentration was tested 3–4 times, and each time, three repeats were used. The median of the data is displayed as a line. (B,D,F) Hemolytic activity against rat red blood cells. Each peptide concentration was tested in triplicate. The data are expressed as the mean ± SD.