TABLE 3.
Predictors of ALT elevations comparing Children with COVID‐19 and MIS‐C
| COVID‐19 | MIS‐C | |||||
|---|---|---|---|---|---|---|
| OR | 95% Confidence interval | P‐value | OR | 95% Confidence interval | P‐value | |
| Age | 1.02 | 0.94‐1.11 | 0.64 | 1.14 | 0.97‐1.34 | 0.11 |
| Male sex | 2.34 | 0.73‐7.46 | 0.15 | 5.29 | 1.25‐22.43 | 0.02 |
| Black race | 0.28 | 0.06‐1.30 | 0.10 | 4.43 | 1.01‐18.81 | 0.04 |
| Obesity | 1.67 | 0.55‐5.07 | 0.37 | ‐ | ‐ | ‐ |
| Chronic liver disease | 2.39 | 0.32‐17.95 | 0.40 | ‐ | ‐ | ‐ |
| ICU admission | 2.63 | 0.66‐10.44 | 0.17 | ‐ | ‐ | ‐ |
| Peak CRP | 1.08 | 1.03‐1.15 | 0.01 | 1.02 | 0.96‐1.08 | 0.63 |
Multivariable logistic regression comparing children without and with elevated ALT. E‐ALT defined as ALT > 40 U/L. Obesity defined as body mass index ≥95th percentile in patients <18 years‐old or ≥30 kg/m2 in patients 19‐21 years‐old, COVID‐19 cohort: ALT ≤ 40 U/L (n = 151) and ALT > 40 U/L (n = 69)
MIS‐C cohort: ALT ≤ 40 U/L (n = 35) and ALT > 40 U/L (n = 36).
Abbreviations: ALT, alanine aminotransferases; CI, Confidence interval; COVID‐19, coronavirus disease‐2019; CRP, c‐reactive protein; MIS‐C, multisystem inflammatory syndrome in children; OR, odds ratio.