FIGURE 1.

A brain–gut connection between migraine and gastric disorders. There is evidence in the literature supporting a brain‐gut connection. ²¹ This review further corroborates this association by providing evidence of shared pathophysiological features, such as alterations in serotonergic signaling ³⁵ , ³⁶ , ³⁷ , ³⁸ , ³⁹ , ⁴⁰ , ⁴¹ , ⁴² , ⁴³ and autonomic dysfunction, ²⁰ , ²² , ²³ , ²⁴ , ²⁶ , ²⁷ , ²⁸ , ³⁰ , ³¹ and overlapping symptomatology between migraine, ¹ , ⁵³ and GI disorders including gastroparesis, functional dyspepsia, and cyclic vomiting syndrome, often presenting as comorbidities in either condition ⁷ , ¹⁰ , ¹¹ , ⁵⁴ , ⁵⁵ , ⁵⁶ , ⁵⁷ , ⁵⁸