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. 2021 Apr 16;60(21):11824–11829. doi: 10.1002/anie.202102754

Figure 1.

Figure 1

a) Selected azetidine‐containing spirocyclic pharmaceuticals. b) Previous work: (i) electrophile‐induced ring opening of ABB and (ii) ABB‐Li in the synthesis of azetidinyl boronic esters. c) This work: strain‐release driven spirocyclization of azabicyclo[1.1.0]butyl ketones. LG=leaving group.