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. 2021 May 6;60(24):13380–13387. doi: 10.1002/anie.202101496

Scheme 1.

Scheme 1

a) Retrosynthesis of IL‐6 glycoforms; b) N‐glycans detected in natural human IL‐6 (values in parentheses give percentage of total N‐glycans and were deduced from ref. [2]); c) structures of N‐glycans envisioned for systematically varied library of hIL‐6 glycoforms. The IL‐6 glycoforms marked in bold (Gn and G2) were available from previous work. [5]