Table 3.
Cytotoxicity (as decrease of cell viability) of ColH inhibitors 26 (ZBG=phosphonate) and 5 a (ZBG=thiol) as well as of three reference compounds against three human cell lines.
|
Compound |
c [μm] |
Decrease of viability [%] after 48 h[a] |
||
|---|---|---|---|---|
|
HepG2 |
HEK293 |
A549 |
||
|
5 a (thiol) |
100 |
15±9 |
53±0 |
18±12 |
|
26 (phosphonate) |
100 |
8±10 |
32±4 |
20±2 |
|
rifampicin |
100 |
33±13 |
29±13 |
9±13 |
|
doxorubicin |
1 |
57±14 |
47±9 |
53±13 |
|
epirubicin |
1 |
68±10 |
49±11 |
56±12 |
[a] Means of at least two independent measurements.