FIGURE 10.

Reduction of the immunosuppressive TME. In combination with PD‐L1 antibody (anti‐PD‐L1), HA‐coated PeiPLGA‐MTX NPs, or only PeiPLGA‐MTX NPs triggered several inflammatory effects in the TME (a–f). The immunohistological panel presents images with 100× magnification; 400× magnification is shown in the lower right corner of each image. Scores were applied to each image to represent them graphically. All data are presented as mean ± SD of six independent values (n = 6) per group with at least two replicates. * P < .05, significantly different as indicated; ^#not significantly different; One‐way ANOVA with post hoc Bonferroni correction or Kruskal–Wallis with post hoc Dunn correction