Figure 1.

Schematic representation of the PEG‐functionalized octahedral cage 1 a, bearing on average 220 repetitive ethylene glycol units at each vertex, leading to a total molar mass of 60 kDa. Activation by ultrasound in aqueous solution leads to fragmentation of the cage, releasing the non‐covalently bound cargo. The preloaded cargo is depicted as the orange dot within the cavity of cage 1 a, representing either precisely one molecule of progesterone or two molecules of ibuprofen per supramolecular entity.