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. 2021 Mar 16;63(4):691–706. doi: 10.1111/jipb.13037

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© 2021 The Authors. Journal of Integrative Plant Biology published by John Wiley & Sons Australia, Ltd on behalf of Institute of Botany, Chinese Academy of Sciences

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Methylation and transcriptome analyses in drdd quadruple mutants

(A) The distribution of hyper‐differentially methylated regions (hyper‐DMRs) in the drdd ^{DD7 pro} quadruple mutant. (B) Heatmap analysis of transcript levels of 205 hyper‐DMR‐associated downregulated differentially expressed genes (DEGs) in the drdd ^{DD7 pro} quadruple mutant. Transcript levels in rdd‐2, dme ^{DD7 pro}, drdd ^{+395 pro}, and drdd ^{DD7 pro} are shown. (C) DNA methylation changes surrounding the 205 downregulated DEGs in the drdd ^{DD7 pro} quadruple mutant. (D) Gene Ontology (GO) analysis of the downregulated DEGs with hyper‐DMRs in the promoter regions in the drdd ^{DD7 pro} quadruple mutant.