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. 2021 Mar 29;40(12):2939–2956. doi: 10.1002/sim.8949

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© 2021 The Authors. Statistics in Medicine published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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SIM-8949-FIG-0007-c — Interim optimization. The color indicates the expected utility given interim data for each combination of second‐stage prevalence $r_{1}^{(2)}$ for subgroup 1 and testing weight $ω_{1}^{(2)}$ given the interim data [Colour figure can be viewed at wileyonlinelibrary.com]