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. 2021 May 14;27(34):8832–8845. doi: 10.1002/chem.202101229

Figure 8.

Figure 8

Binding mode of (R,R)‐trans‐δ‐viniferin and (S,S)‐trans‐δ‐viniferin when docked into Pu22T14T23 G‐quadruplex. The four panels represent the four possible 1 : 2 DNA/ligand complexes which can be formed between Pu22T14T23 G‐quadruplex and the two enantiomers targeting the 5’‐end quartet (top) and/or the 3’‐end quartet (bottom) as follows: A) 5’‐end quartet: (R,R)‐trans‐δ‐viniferin, 3’‐end quartet: (R,R)‐trans‐δ‐viniferin, B) 5’‐end quartet: (S,S)‐trans‐δ‐viniferin, 3’‐end quartet: (S,S)‐trans‐δ‐viniferin, C) 5’‐end quartet: (R,R)‐trans‐δ‐viniferin, 3’‐end quartet: (S,S)‐trans‐δ‐viniferin and D) 5’‐end quartet: (S,S)‐trans‐δ‐viniferin, 3’‐end quartet: (R,R)‐trans‐δ‐viniferin. (R,R)‐trans‐δ‐viniferin and (S,S)‐trans‐δ‐viniferin are represented as cyan and green sticks, respectively.