Table 5.
Cytotoxic activity of the here investigated natural stilbenoids.[a]
|
Compound |
A375 |
H460 |
PC3 |
WS1 |
|---|---|---|---|---|
|
IC50 (μM)[b] |
|
|
|
|
|
(±)‐trans‐δ‐viniferin |
95±7 |
81±4 |
120±7.8 |
69±5.6 |
|
trans‐resveratrol |
44.5±3.5 |
25±0.77 |
>100 |
>200 |
|
trans‐pterostilbene |
33±0.7 |
25±0.4 |
97±4.9 |
57±10 |
|
(±)‐pterostilbene‐trans‐dihydrodimer |
25.5±2.12 |
24.7±0.35 |
42.7±0.5 |
82.7±1.06 |
[a] 24 h after seeding, cells were exposed for 48 h to the compounds and cytotoxicity was measured using MTS assay. Data represent mean values ±SD of three independent experiments. [b] IC50 is defined as the concentration of compound causing 50 % cell growth inhibition.