Figure 2.

Cellular uptake of the binding‐mediated ribonucleoprotein corona. a) Quantification of cell uptake by measuring intracellular AuNPs using ICP‐MS. Cells were incubated for 4 h with different RNP coronae (10 nM) of increasing Cas9 density. b) TEM characterization of cell internalization of the RNP corona (10:1) after incubation (10 nM) with Hela cells for 15 min and 60 min. c) Cellular uptake of the RNP corona and sgRNA‐AuNPs in the presence and absence of 10 % FBS.