FIGURE 3.

Regional association plot of chromosome 17q21.32 with lead single nucleotide polymorphism (SNP) rs11871306 demonstrating an association with relapse hazard. Association results (primary y‐axis) are shown for genetic variants with a minor allele frequency (MAF) ≥2% and imputation INFO metric ≥0.9, along with recombination rates (secondary y‐axis), for a 500 kb region (250 kb region flanking the lead SNP rs11871306 (chr17:44954984 (hg19)). Each dot represents the ‐log₁₀ p value from the survival analysis using the Cox proportional hazards model including baseline relapses before any immunomodulatory treatment. Genetic variants are colored according their linkage disequilibrium (LD; r ²) with the lead SNP using the 1,000 Genomes Phase III EUR superpopulation.