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A) Platinum (ppb, ▴) and phosphorus (ppb, •) bound to salmon testes DNA incubated with Left: 1 or right: cisplatin for different incubation times (0–48 h). [DNA]=9×10−4 m, [DNA]/[complex]=10. The data represent the mean±SD of four experiments. B) Formation of interstrand crosslinks in the presence of increasing concentrations of 1 (1–30 μm) or 1 μm cisplatin (cis‐Pt). The linearized untreated ds‐DNA and urea/heat‐denatured ss‐DNA are also shown for reference.
