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. 2021 Apr 6;16(12):1956–1966. doi: 10.1002/cmdc.202100075

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© 2021 The Authors. ChemMedChem published by Wiley-VCH GmbH

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Analysis of the effect of the platinum complexes on mitochondria. A) Cytofluorimetric analysis of mitochondrial transmembrane potential (ΔΨ) in A2780cis cells in the presence of 1 or cisplatin (cis‐Pt) at the indicated concentrations for 40 h. B) Measurement of ROS production in cells upon incubation with the platinum complexes. A2780cis cells (10 000/well) were treated with increasing concentrations of 1, 2 or cis‐Pt, and short‐term ROS production was assessed by means of the CM‐DCFDA probe. Results are reported as percentage ROS production with respect to the control. For both experiments mean values ±SD of four experiments are reported.