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. 2021 Mar 12;27(27):7533–7541. doi: 10.1002/chem.202100328

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© 2021 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Effect of serotonin on the interaction of RN46A cells with amylin (IAPP) and transferrin. (A,B) Confocal images of the binding and internalization of Rhodamine (Rh)‐labelled IAPP oligomers to RN46A cells in the absence (A) and in the presence (B) of serotonin. (C,D) Confocal images of transferrin receptor internalization by RN46A cells showing AlexaFluor488‐transferrin distribution in absence (C) and in presence (D) of serotonin. (E) analysis of the extent of binding of different probes in absence (black) and in presence (red) of serotonin. Cells are pre‐treated with 5‐HT1A receptor antagonist, WAY100635 (10 μm), 5‐HT2 receptor antagonists Methysergide (10 μm) and Ketanserin (10 μm), and SERT inhibitor Fluoxetine (10 μm).