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. 2021 May 6;193(6):1203–1212. doi: 10.1111/bjh.17470

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© 2021 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Fig 3 — Measurements of a universal, low‐molecular‐weight heparin (LMWH)‐calibrated anti‐Xa assay in relation to drug concentrations in a multicentre cross‐sectional study conducted in clinical practice (n = 867). Drug concentrations were determined using ultra‐high performance liquid chromatography‐tandem mass spectrometry (LC‐MS/MS). Of the patients, 375 were taking rivaroxaban, 426 apixaban and 66 edoxaban. Spearman correlation coefficient was 0·99 for rivaroxaban (95% CI 0·98–0·99), 0·97 for apixaban (95% CI 0·96–0·97), and 0·98 for edoxaban (95% CI 0·95–0·99).