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Regulation by PML-II of IFNα-induced cell death. IFN stimulation increases the expression of PML-II which in turn positively regulates IFNα-induced pro-apoptotic protein expression, contributing to IFNα-mediated anti-tumour activity. The intrinsic inhibitory effect of PML-II on AKT and ERK signaling also contributes to IFNα exerting this function
