Table 4.
Association between DNA methylation and behavior reports in individuals with 49,XXXXY
| CBCL total problems (95% CI) | P value | CBCL externalizing problems (95% CI) | P value | CBCL internalizing problems (95% CI) | P value | |
|---|---|---|---|---|---|---|
| MAOA CpG-1 | 0.32 (− 0.03, 0.67) | 0.08 | 0.30 (− 0.03, 0.62) | 0.08 | 0.32 (− 0.09, 0.73) | 0.13 |
| MAOA CpG-2 | 0.27 (0.0002, 0.54) | 0.06 | 0.31 (0.07, 0.55) | 0.02 | 0.16 (− 0.16, 0.49) | 0.33 |
| MAOA CpG-3 | 0.33 (− 0.07, 0.73) | 0.12 | 0.40 (0.04, 0.76) | 0.04 | 0.23 (− 0.24, 0.70) | 0.35 |
| MAOA CpG-4 | 0.25 (− 0.06, 0.56) | 0.13 | 0.32 (0.04, 0.60) | 0.03 | 0.12 (− 0.25, 0.50) | 0.52 |
| MAOA CpG-5 | 0.20 (− 0.07, 0.47) | 0.17 | 0.24 (− 0.004, 0.49) | 0.06 | 0.15 (− 0.17, 0.47) | 0.38 |
| MAOA CpG-6 | 0.22 (− 0.07, 0.50) | 0.15 | 0.26 (− 0.001, 0.52) | 0.06 | 0.15 (− 0.18, 0.49) | 0.38 |
| MAOA CpG-7 | 0.22 (− 0.02, 0.45) | 0.08 | 0.27 (0.06, 0.47) | 0.02 | 0.13 (− 0.15, 0.40) | 0.38 |
| AR CpG-1 | 0.99 (− 0.14, 1.84) | 0.07 | 1.05 (− 0.002, 2.11) | 0.11 | 0.56 (− 0.28, 1.41) | 0.25 |
| AR CpG-2 | 1.33 (− 0.10, 2.57) | 0.09 | 1.38 (− 0.16, 2.92) | 0.14 | 0.71 (− 0.51, 1.93) | 0.31 |
| AR CpG-3 | 0.36 (− 0.44, 1.16) | 0.42 | 0.32 (− 0.63, 1.26) | 0.54 | 0.19 (− 0.48, 0.86) | 0.61 |
| AR CpG-4 | 1.16 (− 0.46, 2.78) | 0.22 | 1.13 (− 0.84, 3.09) | 0.31 | 0.68 (− 0.74, 2.10) | 0.39 |
| BRIEF Behavioral Regulation Index (95% CI) | P value | BRIEF Metacognition Index (95% CI) | P value | BRIEF Global Executive Composite (95% CI) | P value | |
|---|---|---|---|---|---|---|
| MAOA CpG-1 | 0.23 (− 0.23, 0.68) | 0.33 | 0.05 (− 0.32, 0.42) | 0.80 | 0.10 (− 0.30, 0.50) | 0.63 |
| MAOA CpG-2 | 0.23 (− 0.14, 0.60) | 0.24 | 0.03 (− 0.28, 0.33) | 0.86 | 0.09 (− 0.24, 0.41) | 0.60 |
| MAOA CpG-3 | 0.25 (− 0.30, 0.79) | 0.39 | 0.06 (− 0.39, 0.50) | 0.81 | 0.11 (− 0.36, 0.59) | 0.65 |
| MAOA CpG-4 | 0.31 (− 0.11, 0.74) | 0.16 | 0.03 (− 0.33, 0.39) | 0.87 | 0.12 (− 0.26, 0.50) | 0.54 |
| MAOA CpG-5 | 0.10 (− 0.26, 0.47) | 0.58 | − 0.02 (− 0.32, 0.27) | 0.88 | 0.01 (− 0.31, 0.32) | 0.97 |
| MAOA CpG-6 | 0.21 (− 0.17, 0.59) | 0.29 | 0.03 (− 0.28, 0.35) | 0.85 | 0.08 (− 0.26, 0.42) | 0.65 |
| MAOA CpG-7 | 0.18 (− 0.14, 0.51) | 0.28 | 0.02 (− 0.25, 0.28) | 0.90 | 0.07 (− 0.22, 0.35) | 0.66 |
| AR CpG-1 | 1.59 (0.63, 2.54) | 0.03 | 0.97 (0.14, 1.80) | 0.08 | 1.11 (− 0.06, 2.28) | 0.13 |
| AR CpG-2 | 1.99 (0.41, 3.58) | 0.07 | 1.22 (− 0.05, 2.48) | 0.13 | 1.40 (− 0.32, 3.12) | 0.19 |
| AR CpG-3 | 0.69 (− 0.40, 1.79) | 0.28 | 0.45 (− 0.33, 1.22) | 0.32 | 0.42 (− 0.63, 1.47) | 0.48 |
| AR CpG-4 | 2.17 (0.26, 4.07) | 0.09 | 1.55 (0.30, 2.80) | 0.07 | 1.55 (− 0.44, 3.53) | 0.20 |
The P value threshold for statistical significance after Bonferroni correction for the number of CpG sites tested was 0.005